Cervical thorium dioxide granuloma ('thorotrastoma').

Coarctation of the aorta and other late sequelae of administration of thorium dioxide (thorotrast).

Coarctation of the aorta secondary to a cervicomediastinal thorotrastoma developed in a 30-year-old man 25 years after carotid arteriography. Other local manifestations of the thorotrastoma included occlusion of the left common carotid artery and partial occlusion of the left vertebral and left subelavian arteries, bilateral recurrent laryngeal nerve paresis, periesophageal adhesions, and multi...

Identification of thorium dioxide in human liver cells by electron microscopic x-ray microanalysis.

Thirty-two years after injection of thorium dioxide (Thorotrast) for diagnostic x-ray studies in a female patient deposits were found by light microscopy in the liver macrophages (Kupffer cells). They were shown by electron microscopy to be located inside secondary lysosomes, and by autoradiography and x-ray microanalysis they were identified as thorium.

The Effectiveness of Colloidal Thorium Dioxide as an Internal Alpha Emitter: A Combined Morphologic and Radioautographic Study ‡

The hazard of ionizing radiation from internally administered colloidal thorium dioxide (Thorotrast) has been a subject of controversy even since this medium was first employed in clinical roentgenology. Reports of neoplasia as well as diffuse hepatic fibrosis occurring in patients following Thorotrast administration have been summarized and evaluated by Thomas et al.7 Although intravenous inje...

The alteration of the lipemia-clearing effect of heparin following the intravenous injection of thorium dioxide (thorotrast).

Configurational analysis of uranium-doped thorium dioxide

While thorium dioxide is already used industrially in high temperature applications, more insight is needed about the behaviour of the material as part of a mixed-oxide (MOX) nuclear fuel, incorporating uranium. We have developed a new interatomic potential model, commensurate with a prominent existing UO2 potential, to conduct configurational analyses of uranium-doped ThO2 supercells. Using th...